Some examples of the goals of clinical trials are:
Many different ways of preventing cancer are studied in cancer prevention trials. Such as:
Also known as Screening Trials - these studies look at ways to find cancer before symptoms appear. Some possible screening methods include:
Example: The National Lung Screening Trial (NLST) compared chest X-rays with another imaging method called spiral CT to see which method is better at finding lung cancer early in people who are at high risk because of heavy smoking
These studies are designed to find more effective treatments for cancer. These studies compare a new treatment with treatments that are being used now.
Possible new treatments include:
Example: Thalidomide was used in Europe to prevent miscarriages in the 1950s. It turned out to cause birth defects because it interfered with the normal development of blood vessels (development of arteries and veins is called angiogenesis). Thalidomide is now used to interfere with the development of blood vessels (anti-angiogenesis) that feed cancerous tumors.
These studies are designed to find better ways to manage cancer treatments and cancer-related side effects. Some possible Quality of Life questions that these studies try to answer include:
Note: Most trials now include evaluation of quality of life (even for people who are not doing well).
Example: A study conducted to evaluate the use of acupressure to reduce nausea and vomiting in patients taking chemotherapy.